MII IG Onkologie DE v2026

Bezug zu nationalen Standards

Beim beschriebenen Basisdatensatz Onkologie handelt es sich um einen Datensatz, der auf dem oBDS und damit den deutschen Krebsregister-Datenmodellen folgt.

Informationssysteme im Krankenhaus(ISiK)

ISiK beschreibt einen Standard, der für Krankenhaussysteme zum Austausch untereinander genutzt werden soll. ISiK selbst enthält wenige inhaltliche Vorgaben und Binding, die für die Erfassung von onkologischen Daten relevant sind. Durch die steigende Bedeutung im Krankenhaussektor wurde bei der Profilierung auf eine Konformität geachtet.

Die Diagnose- und Prozedur-Profile sind Teil der ISiK-Basismodule https://simplifier.net/guide/isik-basis-v4?version=current
Medikation ist Teil des ISiK-Medikationsmoduls https://simplifier.net/guide/isik-medikation-v4?version=current

Medizinische Informationsobjekte (MIOs)

MIOs sind als strukturierte Datenelemente im Kontext der elektronischen Patientenakte (ePA) von Bedeutung. Der erste große Baustein soll dabei eine Bereistellung von strukturierten Medikationsdaten Zum Zeitpunkt der Erstellung der Profilierung (Jan-Apr 2024) befanden sich die Profile für Medikation / Medikationsplan noch in der Profilierung und konnten daher in der vorliegenden Spezifikation keine Berücksichtigung finden. Zu beachten ist dabei aber, dass die Medikationsliste und die Tumordokumentation momentan noch getrennte Ökosysteme sind. Eine langfriste Harmonisierung von vergleichbaren Profilen wird ab 2025 durch das KIG der gematik koordiniert und vorangetrieben. Der Implementierungsleitfaden für den "ePA Medication Service" befindet sich hier: https://simplifier.net/guide/medication-service?version=1.1.0 Link zum konkreten Profil EPA MedicationStatement https://simplifier.net/epa-medication/epamedicationstatement

Nationale Vorarbeiten

German OncoLogical Data Standard (GOLD)

Das Projekt GOLD befasst sich als Teil der Vison Zero Oncology oncology . Das Datenmodell und die dazugehörigen Profile wurden von existierenden Datenmodellen abgeleitet und mit deutschen Experten abgestimmt. Gleichzeitig wurden Anstrengungen in Richtung einer semantischen Harmonisierung von verschiedenen Datenmodellen aus Forschung und Industrie unternommen. Die ersten Profile haben den Fokus auf Diagnose und Klassifikationen, wie die TNM-Klassifikation. Die aktuelle Version ist hier zu finden: https://vision-zero-oncology.github.io/GOLD/

Basisprofile Onkologie von HL7 Deutschland

In den Basisprofilen Deutschland wurden insb. 2022 Profilierungsarbeiten für eine Grundlage der einheitlichen Verwendung von FHIR-Ressourcen im onkologischen Sektor geliefert. https://simplifier.net/BasisprofileOnkologie Die Arbeiten an den Basisprofilen ruhen seit der Kommentierung 2022. Mittlerweile verweisen die Basisprofile Onkologie der HL7 auf das hier vorliegende Erweiterungsmodul Onkologie der MII.

Deutsches Konsortium für Translationale Krebsforschung

Das interne Datenmodell der DKTK nutzt aus den Tumordokumentationssystemen aufbereitete oBDS-Daten im FHIR-Format als Austauschmedium. (erreichbar unter https://simplifier.net/oncology) Das ursprüngliche Informationsmodell des Erweiterungsmoduls Onkologie war stark am DKTK-Modell orientiert. Die Profilierung unterscheidet sich jedoch insofern, als dass die DKTK-Profile in sich abgeschlossen sind, während ein MII-Modul möglichst gut mit den MII-Basismodulen (v.a. Diagnose, Prozedur, Medikation) und bereits bestehenden Erweiterungsmodulen arbeiten soll. Daher war einer der Hauptmodellierungsentscheidungen die Verwendung der MII-Diagnose und MII-Medikation, sowie die Darstellung von OPs, Strahlentherapien und Systemischen / abwartenden Therapien als MII-Prozeduren.

Modellvorhaben Genomsequenzierung

Das Modellvorhaben Genomsequezierung nach §64e SGB V sieht die Erhebung eines Datenkranzes bei einer Next-Generation-Sequenzierung (NGS) von onkologischen Patienten vor. Der Datenkranz beinhaltet dabei Informationen zur diagnostischen und therapeutischen Vorgeschichte, der molekulargenetischen Beschreibung des Tumors, den Empfehlungen zu Studienteilnahmen und systemischen Therapien sowie Follow-up-Informationen zu tatsächlich durchgeführten Therapien und Therapieansprechen / Vitalstatus.

Es gibt einen ähnlichen Datenkranz für Seltene Erkrankungen, der zukünftig im Modul Seltene Erkrankungen abgebildet wird.

MII_LM_MVGenomSeq_Onkologie (mii-lm-mvgenomseq-onkologie)			Element	Element id mii-lm-mvgenomseq-onkologie Short description MII LM Modellvorhaben Genomsequenzierung Onkologie Definition MII LogicalModel Modellvorhaben Genomsequenzierung Onkologie Data type Element Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
OnkologieFall		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall Short description Onkologie-Fall Definition Onkologie-Fall Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Diagnose		1..1	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose Short description Diagnose Definition Diagnose Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a MVGenomSeq-Datenkranz-to-MII-FHIR: Condition
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Haupttumordiagnose		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.Haupttumordiagnose Short description Haupttumordiagnose Definition Haupttumordiagnose in ICD-10-GM Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Condition.code.coding.where(system='http://fhir.de/CodeSystem/bfarm/icd-10-gm').code
WeitereOnkologischeDiagnosen		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.WeitereOnkologischeDiagnosen Short description Weitere onkologische Diagnosen Definition Optional bei mehreren onkologischen Diagnosen, insbesondere Dokumentation als weiter onkologische Diagnose bei hereditären Tumordispositionssydroms (HT), bei HT zusätzliche Dokumentation ORPHAcode oder AlphaID, ein Code soweit vorhanden ist. Undiagnostizierte Erkrankungen sind mit ORPHA:616874 zu kodieren. Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Condition.code.coding.where(system='http://fhir.de/CodeSystem/bfarm/icd-10-gm').code
Hauptdiagnosedatum		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.Hauptdiagnosedatum Short description Hauptdiagnosedatum Definition Datum der Erstdiagnose der Hauptdiagnose. Wenn Tag unbekannt -> 15. des Monats Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Condition.extension.where(url='http://hl7.org/fhir/StructureDefinition/condition-assertedDate').valueDate
ECOGStatus		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.ECOGStatus Short description ECOG-Status Definition Eastern Cooperative Oncology Group (ECOG) Performance Status nach 0,1,2,3,4,5,unknown, not applicable Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Observation.where(code='423740007' and system='http://snomed.info/sct').valueCodeableConcept.coding.code
KeimbahndiagnoseVorhanden		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.KeimbahndiagnoseVorhanden Short description Keimbahndiagnose vorhanden Definition Ja, Nein, unbekannt Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: no direct match, vsl. über FHIRPath automatisch generieren, wenn Keimbahndiagnose.exists()
Keimbahndiagnose		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.Keimbahndiagnose Short description Keimbahndiagnose Definition Keimbahndiagnosen nach ICD-10-GM.Bei Diagnose eines hereditären Tumordispositionssydroms als Teil der OE ist verpflichtend anzugeben mit ICD10 und ORPHA oder AlphaID Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: no direct match. Keimbahndiagnose existiert als Konzept nicht, hier könnte / müsste mit Condition.category gearbeitet werden, z.B. SNOMED Hereditary cancer-predisposing syndrome (disorder)
HPOPhaenotypisierung		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.HPOPhaenotypisierung Short description Phänotypisierung nach HPO Definition Human Phenotype Ontology.Bei Diagnose eines hereditären Tumordispositionssydroms als Teil der OE, wenn vorhanden angeben (optional) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Observation.where(valueCodeableConcept.coding.system='http://human-phenotype-ontology.org')
Histologie		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.Histologie Short description Histologie nach ICD-O-3 Definition Histologische Morphologie und Verhalten nach ICD-O-3 Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Condition.extension.where(url='https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-histology-morphology-behavior-icdo3').valueCodeableConcept.coding.code
Topographie		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.Topographie Short description Topographie nach ICD-O-3 Definition Topographie des Tumors nach ICD-O-3 Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Condition.bodySite.coding.code
Grading		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.Grading Short description Differenzierungsgrad Definition Gibt den Differenzierungsgrad des Tumors entsprechend der aktuellen TNM-Auflage an, Bei der Klassifikation sind die einschlägigen Regeln der Literatur (TNM) zu beachten. Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Observation.where(code.coding.code='33732-9' and code.coding.system='http://loinc.org').valueCodeableConcept.coding.code
TNMSchluessel		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.TNMSchluessel Short description TNM-Klassifikation Definition TNM-Klassifikation des Tumors Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Observation.where(code.coding.code='33732-9' and code.coding.system='http://snomed.info/sct').valueCodeableConcept.coding.code
TNMSystematik		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.TNMSystematik Short description TNM-Systematik Definition TNM-Systematik nach AJCC oder UICC Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Laut Krebsregisterdaten nur UICC vorgesehen? kein expiziter Datenpunkt außer Version
WeitereKlassifikationen		0..*	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.WeitereKlassifikationen Short description Weitere Klassifikationen Definition Weitere Klassifikationen des Tumors zum Diagnosezeitpunkt Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: no direkt match - Observation - Nutzung des Profils WeitereKlassifikationen, aber aufgrund der Vielfalt der Klassifikationen keine direkte Zuordnung möglich
DiagnostischeVoruntersuchungen		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Diagnose.DiagnostischeVoruntersuchungen Short description Diagnostische Voruntersuchungen Definition Diagnostische Voruntersuchungen zum Diagnosezeitpunkt. Bewertung der durchgeführten genetischen Diagnostik, nur für heriditäre Prädispositionssyndrome/ Erbliche Tumore Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: no direkt match
Vordiagnostik		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Vordiagnostik Short description Vordiagnostik Definition Vordiagnostik Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a MVGenomSeq-Datenkranz-to-MII-FHIR: Vordiagnostik
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Vordiagnostik.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Vordiagnostik.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Vordiagnostik.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
ArtDiagnostik		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Vordiagnostik.ArtDiagnostik Short description Diagnostik Definition Diagnostik, die vor dem MV Genomseq, durchgeführt wurde (Vorbefunde) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Diagnoste)
DatumDiagnostik		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.Vordiagnostik.DatumDiagnostik Short description Datum Definition Datum der Diagnostik Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Datum Diagnostik
MolekulareVorbefunde		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde Short description klinisch relevante Ergebnisse der Diagnostik Definition klinisch relevante Ergebnisse der Diagnostik Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a MVGenomSeq-Datenkranz-to-MII-FHIR: klinisch relevante Ergebnisse der Diagnostik
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Gen		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.Gen Short description Gen Definition Gen kodiert nach HGNC Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Genert nach HGNC
Transkript		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.Transkript Short description Transkript Definition Transkript kodiert nach Ensembl/RefSeq Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Transkriranskript kodiert nach Ensembl/RefSeq
DNAChange		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.DNAChange Short description DNA-Veränderung Definition DNA-Verändung nach cHGVS Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: DNA-VeränVerändung nach cHGVS
ProteinChange		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.ProteinChange Short description Protein-Veränderung Definition Protein-Veränderung nach pHGVS Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Protein-Verändotein-Veränderung nach pHGVS
TypAlteration		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.TypAlteration Short description Typ der Alteration Definition Typ der Alteration / Variantenklasse nach Sequence ontology (SO) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Typ der Alteratr Alteration / Variantenklasse nach Sequence ontology (SO)
KomplexeAlteration		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.MolekulareVorbefunde.KomplexeAlteration Short description Komplexe Alteration Definition Ausführliche Beschreibung bei komplexen Alteration z.B. Fusion Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Komplexe AlteratAusführliche Beschreibung
SystemischeVortherapien		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien Short description Systemische Vortherapien Definition Systemische Vortherapien Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a MVGenomSeq-Datenkranz-to-MII-FHIR: Procedure
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
ArtTherapie		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.ArtTherapie Short description Bezug zur operativen Therapie Definition Bezug der Vortherapie zu einer operativen Therapie, z.B. adjuvant, neoadjuvant Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Procedure.extension.where(url='StellungZurOp')
IntentionTherapie		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.IntentionTherapie Short description Intention Definition Intention der Vortherapie, z.B. kurativ, palliativ Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Procedure.extension.where(url='Intention')
Substanz		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.Substanz Short description Substanz Definition Substanz der Vortherapie nach ATC oder Text bei nicht-ATC-Wirkstoffen Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: MedicationStatement.medicationCode.coding[atc-de].code
Therapiestart		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.Therapiestart Short description Startdatum Definition Startdatum der Vortherapie. Wenn Datum unbekannt, dann 15. des Monats Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Procedure.effectivePeriod.start
Therapieende		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.Therapieende Short description Enddatum Definition Enddatum der Vortherapie. Wenn Datum unbekannt, dann 15. des Monats Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Procedure.effectivePeriod.end
EndeGrund		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.EndeGrund Short description Ende der Therapie Definition Grund für das Ende der Vortherapie Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Procedure.outcome
TherapieAnsprechen		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.TherapieAnsprechen Short description Ansprechen Definition Therapieansprechen der fallrelevante, systemische Vortherapie (PD: Progression, SD:Stabile Erkrankung, PR:Partielle Remission, CR:Komplette Remission) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Verlauf.valueCodeableConcept.coding.code
TherapieAnsprechenDatum		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFall.SystemischeVortherapien.TherapieAnsprechenDatum Short description Datum Definition Datum des Ansprechens der Vortherapie Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings MVGenomSeq-Datenkranz-to-MII-FHIR: Verlauf.effectiveDateTime
OnkologieMolekular		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular Short description Molekulare Diagnostik Definition Molekulare Diagnostik Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
EinfacheVariante		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante Short description Einfache Variante inkl. Fusionen im codierenden Bereich Definition Einfache Variante inkl. Fusionen im codierenden Bereich Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Identifier		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.Identifier Short description Identifier Definition interner Identifikator der Variante Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Gen		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.Gen Short description Gen Definition Gen kodiert nach HGNC Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Transkript		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.Transkript Short description Transkript Definition Transkript kodiert nach Ensembl/RefSeq Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
DNAChange		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.DNAChange Short description DNA-Veränderung Definition DNA-Verändung nach cHGVS Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
ProteinChange		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.ProteinChange Short description Protein-Veränderung Definition Protein-Veränderung nach pHGVS Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TypAlteration		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.TypAlteration Short description Typ der Alteration Definition Typ der Alteration / Variantenklasse nach Sequence ontology (SO) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Lokalization		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.Lokalization Short description Lokalisation der Variante Definition Lokalisation im kodierenden, regulatorischen oder intergenischen Bereich Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
LossOfHeterozygosity		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.EinfacheVariante.LossOfHeterozygosity Short description Loss of Heterozygosity (LOH) Definition Loss of Heterozygosity (LOH) im Bereich der Variante Ja / Nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
CopyNumberVariante		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante Short description Variante mit Kopienzahlveränderung (Copy Number Variation, CNV) Definition Variante mit Kopienzahlveränderung (Copy Number Variation, CNV) Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Identifier		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.Identifier Short description Identifier Definition interner Identifikator der Variante Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
CNVTyp		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.CNVTyp Short description CNV-Typ Definition Komplettverlust, partieller Verlust, Amplifikation Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
Quellprobe		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.Quellprobe Short description Art der Quellprobe Definition Art der Quellprobe (somatisch oder Keimbahn) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Gen		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.Gen Short description Gen Definition Gen kodiert nach HGNC - falls nur ein Gen betreffend Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Chromosom		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.Chromosom Short description Chromosom Definition Chromosom Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
CNVStartPosition		0..1	integer	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.CNVStartPosition Short description CNV-Start Definition Startposition des CNV basierend auf Hg38 Comments 32 bit number; for values larger than this, use decimal Data type integer Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
CNVEndPosition		0..1	integer	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.CNVEndPosition Short description CNV-Ende Definition Endposition des CNV basierend auf Hg38 Comments 32 bit number; for values larger than this, use decimal Data type integer Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
CopyNumber		0..1	integer	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.CopyNumber Short description Copy Number Definition Copy Number Comments 32 bit number; for values larger than this, use decimal Data type integer Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Lokalization		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.CopyNumberVariante.Lokalization Short description Lokalisation der Variante Definition Lokalisation im kodierenden, regulatorischen oder intergenischen Bereich Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
StrukturelleVariante		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante Short description Strukturelle Variante Definition Strukturelle Variante Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Identifier		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.Identifier Short description Identifier Definition interner Identifikator der Variante Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Quellprobe		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.Quellprobe Short description Art der Quellprobe Definition Art der Quellprobe (somatisch oder Keimbahn) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Gen		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.Gen Short description Gen Definition N-terminales Gen Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
GenC		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.GenC Short description Gen Definition C-terminales Gen, falls in-frame und kodierend Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
StrukturTyp		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.StrukturTyp Short description Variantentyp Definition Variantentyp (Inversion, Translokation, Deletion, Insertion, Duplikation) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Beschreibung		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.Beschreibung Short description Beschreibung der Variante Definition Beschreibung der Variante nach HGVS oder ISCN Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Nachweismethode		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.Nachweismethode Short description Nachweismethode Definition Nachweismethode (DNA / RNA) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Lokalization		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.StrukturelleVariante.Lokalization Short description Lokalisation der Variante Definition Lokalisation im kodierenden, regulatorischen oder intergenischen Bereich Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
ExpressionsVariante		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante Short description Expressionsvariante Definition Expressionsvariante Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Identifier		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.Identifier Short description Identifier Definition interner Identifikator der Variante Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Gen		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.Gen Short description Gen Definition Gen kodiert nach HGNC Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Expression		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.Expression Short description Expression Definition Expression des Gens (über- oder unterexprimiert) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Bewertungsgrundlage		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.Bewertungsgrundlage Short description Bewertungsgrundlage Definition Bewertungsgrundlage der Expression (z.B. Vergleichskohorte von 400 Patienten) Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TMB		0..1	decimal	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.TMB Short description Tumor Mutational Burden (TMB) Definition Tumor Mutational Burden (TMB) in Mut/Mb Comments Do not use an IEEE type floating point type, instead use something that works like a true decimal, with inbuilt precision (e.g. Java BigInteger) Data type decimal Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
HRD		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.HRD Short description Homologous Recombination Deficiency (HRD) Definition Homologous Recombination Deficiency (HRD) erhöht ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
LST		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.LST Short description Large Scale Transition (LST) Definition Large Scale Transition (LST) erhöht ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TAI		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.TAI Short description Telomeric Allelic Imbalance (TAI) Definition Telomeric Allelic Imbalance (TAI) erhöht ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
SBS		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.SBS Short description Single Base Substitution (SBS) Definition Single Base Substitution (SBS) erhöht ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
SBSSignature		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.SBSSignature Short description Single Base Substitution Signature Definition Single Base Substitution Signature Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Lokalization		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieMolekular.ExpressionsVariante.Lokalization Short description Lokalisation der Variante Definition Lokalisation im kodierenden, regulatorischen oder intergenischen Bereich Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
OnkologiePlan		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan Short description Therapieplan Definition Therapieplan Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
MolekularesTumorboard		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard Short description Molekulares Tumorboard Definition Molekulares Tumorboard Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Datum		1..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.Datum Short description Datum Definition Datum des Tumorboards Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungStudie		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.EmpfehlungStudie Short description Empfehlung Studie Definition Empfehlung zur Studienteilnahme ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungBeratung		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.EmpfehlungBeratung Short description Empfehlung humangenetische Beratung Definition Empfehlung zu einer humangenetischen Beratung ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungReevaluation		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.EmpfehlungReevaluation Short description Empfehlung Reevaluation Definition Empfehlung zur Reevaluation der molekularen Diagnostik ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungOperation		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.EmpfehlungOperation Short description Empfehlung Operation Definition Empfehlung zur Operation ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungOperationArt		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.EmpfehlungOperationArt Short description empfohlenene Operation Definition empfohlenen Operation Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungOperationRisikoreduzierend		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.EmpfehlungOperationRisikoreduzierend Short description empfohlene Operation ist riskoreduzierend Definition empfohlenen Operation ist riskoreduzierend ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungOperationTherapeutisch		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.EmpfehlungOperationTherapeutisch Short description empfohlene Operation ist therapeutisch Definition empfohlenene Operation ist therapeutisch ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
DurchgefuehrteOperation		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.MolekularesTumorboard.DurchgefuehrteOperation Short description Durchgeführte Operation Definition Durchgeführte Operation nach OPS inkl. Version Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfohleneStudie		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie Short description Empfohlene Studieneinschlüsse Definition Empfohlene Studieneinschlüsse Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Identifier		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.Identifier Short description Identifier Definition interner Identifikator der Studie Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Register		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.Register Short description Register Definition Registersystematik, in dem die StudienID angegeben wird (NCT, EudraCT/CTIS, DRKS, andere, unbekannt) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
StudienID		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.StudienID Short description Studie Definition StudienID in einer Registersystematik Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Studienname		1..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.Studienname Short description Name der Studie Definition Name der Studie Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Substanzen		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.Substanzen Short description Substanzen Definition Substanzen, die in der Studie eingesetzt werden, nach ATC kodiert Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Evidenzgrad		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.Evidenzgrad Short description Evidenzgrad Definition Evidenzgrad Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
ZusatzverweiseEvidenzgraduierung		0..*	string	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.ZusatzverweiseEvidenzgraduierung Short description Zusatzverweise zur Evidenzgraduierung Definition Zusatzverweise zur Evidenzgraduierung Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Prioritaet		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.Prioritaet Short description Priorität Definition Priorität der Studie, falls mehrere Studien empfohlen wurde. 1 ist höchste Priorität Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Variante		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.EmpfohleneStudie.Variante Short description Variante Definition interne VariantenID der Variante, die für die Studie relevant ist Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Therapieempfehlung		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung Short description String Definition String Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Identifier		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.Identifier Short description Identifier Definition interner Identifikator der Therapieempfehlung Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
EmpfehlungTyp		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.EmpfehlungTyp Short description Typ der Empfehlung Definition Typ der Empfehlung (z.B. inlabel, offlabel, compassionate use, unknown, secondary preventive) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Substanz		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.Substanz Short description Substanzen Definition Substanzen, die empfohlen werden, nach ATC kodiert Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Evidenzgrad		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.Evidenzgrad Short description Evidenzgrad Definition Evidenzgrad (m1A - m4, unbekannt) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Prioritaet		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.Prioritaet Short description Priorität Definition Priorität der Therapieempfehlung, falls mehrere Empfehlungen gegeben wurden. 1 ist höchste Priorität Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Variante		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.Variante Short description Variante Definition interne VariantenID der Variante, die für die Therapieempfehlung relevant ist Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TherapeutischeStrategie		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.Therapieempfehlung.TherapeutischeStrategie Short description Therapeutische Strategie Definition Therapeutische Strategie (z.B. zielgerichtete Therapie, Immuntherapie, Chemotherapie, supportive Therapie) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
PraeventiveUntersuchungen		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.PraeventiveUntersuchungen Short description Präventive Maßnahmen Definition Präventive Maßnahmen Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.PraeventiveUntersuchungen.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.PraeventiveUntersuchungen.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.PraeventiveUntersuchungen.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Identifier		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.PraeventiveUntersuchungen.Identifier Short description Identifier Definition interner Identifikator der präventiven Maßnahme Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
ArtUntersuchung		0..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologiePlan.PraeventiveUntersuchungen.ArtUntersuchung Short description Art der Untersuchung Definition Art der Untersuchung(z.B. Breast Imaging, MRI, MGR, US;Colonoscopy ; Esophago-gastro-duodenoscopy ) Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
OnkologieFollowup		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup Short description Follow-up und Umsetzung der Therapieempfehlung Definition Follow-up und Umsetzung der Therapieempfehlung Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
Datum		1..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Datum Short description Datum Definition Datum des Follow-up Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
MetachroneTumore		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.MetachroneTumore Short description Auftreten Metachroner Tumore Definition Auftreten metachroner Tumore ja/nein Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
MetachroneDiagnose		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.MetachroneDiagnose Short description Diagnose Definition Diagnose des metachronen Tumors laut ICD-10 Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
ECOG		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.ECOG Short description ECOG-Status Definition Eastern Cooperative Oncology Group (ECOG) Performance Status nach 0,1,2,3,4,5,unknown, not applicable Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Vitalstatus		1..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Vitalstatus Short description Vitalstatus Definition Vitalstatus des Patienten zum Zeitpunkt des Follow-ups (lebend, verstorben, unbekannt) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
LetzterKontakt		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.LetzterKontakt Short description Letzter Kontakt Definition Datum des letzten Kontakts Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Todesdatum		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Todesdatum Short description Todesdatum Definition Datum des Todes Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
Therapien		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien Short description Therapien Definition Therapien Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
reference		1..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.reference Short description Referenz Studien-/ Therapieempfehlung Definition Referenz auf Studien- / Therapieempfehlung Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TherapieStart		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.TherapieStart Short description Startdatum Definition Startdatum der Therapie Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TherapieEnde		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.TherapieEnde Short description Enddatum Definition Enddatum der Therapie Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TherapieWirkstoff		0..*	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.TherapieWirkstoff Short description Wirkstoff Definition Wirkstoff der Therapie nach ATC oder Text bei nicht-ATC-Wirkstoffen Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TherapieAnsprechen		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.TherapieAnsprechen Short description Ansprechen Definition Therapieansprechen der Therapie (PD: Progression, SD:Stabile Erkrankung, PR:Partielle Remission, CR:Komplette Remission) Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TherapieAnsprechenDatum		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.TherapieAnsprechenDatum Short description Datum Definition Datum des Ansprechens der Vortherapie Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
TherapieEndeGrund		0..1	code	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.TherapieEndeGrund Short description Ende der Therapie Definition Grund für das Ende der Vortherapie Data type code Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
DatenquelleTherapieansprechen		1..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.Therapien.DatenquelleTherapieansprechen Short description Datenquelle Therapieansprechen Definition Datenquelle des Therapieansprechens (z.B. Arztbrief, Entlassungsbericht, Tumordokumentation) Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
PraeventiveMassnahmen		0..*	BackboneElement	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.PraeventiveMassnahmen Short description Präventive Maßnahmen Definition Präventive Maßnahmen Data type BackboneElement Conditions The cardinality or value of this element may be affected by these constraints: ele-1 Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` Mappings rim: n/a
id		0..1	string	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.PraeventiveMassnahmen.id Short description Unique id for inter-element referencing Definition Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces. Data type string Mappings rim: n/a
extension	C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.PraeventiveMassnahmen.extension Short description Additional content defined by implementations Alternate names extensions, user content Definition May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Slicing Unordered, Open, by url(Value) Extensions are always sliced by (at least) url Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: n/a
modifierExtension	Σ ?! C	0..*	Extension	There are no (further) constraints on this element Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.PraeventiveMassnahmen.modifierExtension Short description Extensions that cannot be ignored even if unrecognized Alternate names extensions, user content, modifiers Definition May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions. Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself). Requirements Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions. Comments There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone. Data type Extension Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())` ext-1: Must have either extensions or value[x], not both `extension.exists() != value.exists()` Mappings rim: N/A
reference		1..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.PraeventiveMassnahmen.reference Short description Referenz präventive Maßnahme Definition interne Referenz auf präventive Maßnahme Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
preventiveMeasureResult		1..1	string	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.PraeventiveMassnahmen.preventiveMeasureResult Short description Ergebnis der präventiven Maßnahme Definition Ergebnis der präventiven Maßnahme (z.B. ohne Befund, benigner Befund, Malignom, unklar) Comments Note that FHIR strings SHALL NOT exceed 1MB in size Data type string Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`
preventiveMeasureDate		0..1	date	Element id mii-lm-mvgenomseq-onkologie.OnkologieFollowup.PraeventiveMassnahmen.preventiveMeasureDate Short description Datum der präventiven Maßnahme Definition Datum der präventiven Maßnahme Data type date Constraints ele-1: All FHIR elements must have a @value or children `hasValue() or (children().count() > id.count())`

Ein Mapping der Datenelemente auf den MII KDS ist derzeit in Arbeit, hier ein erster Ausschnitt.

MII_KDS	MII_Display	MVGenomSeq	MVGenomSeq_Display	Aequivalenz	Kommentar
Condition.code	Diagnose Primärtumor	diagnosisOd.mainDiagnosis	Haupttumordiagnose	equivalent	Abbildung über ICD-10-GM-Coding Code/System/Version
Condition.extension:Feststellungsdatum	Feststellungsdatum	diagnosisOd.mainDiagnosis.date	Datum der Diagnose	equivalent	Wenn Tag unbekannt, soll auf 15. gesetzt werden
Condition.bodySite.coding:icd-o-3.code	ICD-O-3 Topographie	diagnosisOd.mainDiagnosis.icdoTopography	ICD-O-3 Topographie	equivalent
Condition.bodySite.coding:icd-o-3.version	ICD-O-3 Version	diagnosisOd.mainDiagnosis.icdoVersion	ICD-O-3 Version	equivalent
Condition.extension:morphology-behavior-icdo3.valueCodeableConcept.coding.code	ICD-O-3 Morphologie-Code	DiagnosisOd.mainDiagnosis.icdoMorphology	ICD-O-3 Morphologie	equivalent
Condition.code.coding	Diagnosecode	DiagnosisOd.additionalDiagnoses	Diagnosecode	narrower	Abbildung über ICD-10-GM/OrphaCode/AlphaID jeweils mit Code/System/Version. Hier hauptsächlich relevante onkologische Begleit- und Vorerkrankungen. Diagnostizierte Keimbahnerkrankungen sollen über
Condition.extension:Feststellungsdatum	Feststellungsdatum	DiagnosisOd.additionalDiagnoses.date	Datum der Diagnose	equivalent	Wenn Tag unbekannt, soll auf 15. gesetzt werden
Condition.code.coding"	Diagnosecode	DiagnosisOd.germlineDiagnoses	Diagnosecode	narrower	Nachgewiesene Keimbahnerkrankungen.Über ICD-10-GM und (OrphaCode und/oder AlphaID) jeweils mit Code/System/Version.
Observation.valueCodeableConcept.coding.code	ECOG-Performance-Status	ecogPerformanceStatusScore	ECOG-Performance-Status	equivalent
Observation.valueCodeableConcept.coding.code	Histologisches Grading	grading	Histologisches Grading	equivalent
Observation.valueCodeableConcept.coding.code	TNM-Klassifikation	ecogPerformanceStatusScore	TNM-KLassifkation	equivalent	für Primärtherapie entscheidendes TNM(auswerterelevanter TNM)
Observation.valueCodeableConcept.coding.code	TNM-T-Kategorie	ecogPerformanceStatusScore	TNM-KLassifkation	equivalent
Observation.valueCodeableConcept.coding.code	TNM-N-Kategorie	ecogPerformanceStatusScore	TNM-KLassifkation	equivalent
Observation.valueCodeableConcept.coding.code	TNM-M-Kategorie	ecogPerformanceStatusScore	TNM-KLassifkation	equivalent