MII IG Modul Molekulargenetischer Befundbericht v2026
PharmGKB Evidence Level Example Codes
CodeSystem
PharmGKB enthält Beispiele für Konzepte der Evidenzstufe, die nicht mit der klinischen Bedeutung verwechselt werden. Diese können auf PharmGKB https://www.pharmgkb.org/page/clinAnnLevels gefunden werden.
Canonical: http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs
Das CodeSystem PharmGKB Evidence Level Example Codes stammt aus HL7 Genomics Reporting Implementation Guide.
Concepts
This code system http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs defines the following codes:
{
--- We have skipped the narrative for better readability of the resource ---
},
],
{
{
},
{
}
]
}
],
"description": "PharmGKB contains examples of evidence level concepts that are not conflated with clinical significance. These can be found on PharmGKB https://www.pharmgkb.org/page/clinAnnLevels. These examples are informational only, for copyright information contact the relevant source.",
{
]
}
],
{
"definition": "High level of evidence. Supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
},
{
"definition": "High level of evidence. But, NOT supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
},
{
"definition": "Moderate level of evidence. Supported by being a KNOWN pharmacogene on https://www.pharmgkb.org/vips. Also, found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
},
{
"definition": "Moderate level of evidence. NOT in the list of very important, KNOWN pharmacogenes. Found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
},
{
"definition": "Low-level of evidence. Where either the assocation is based on a single study, failed to be reproduced, or preliminary evidence."
},
{
"definition": "The evidence does not support an association between the variant and the drug phenotype. (negative)"
}
]
}